UnivTrevesV1, Main, Exploration, bibRecord, 000678

A Randomized, Double-blind, Placebo-controlled Study to Assess QTc Interval Prolongation of Standard Dose Aflibercept in Cancer Patients Treated With Docetaxel

Identifieur interne : 000678 ( Main/Exploration ); précédent : 000677; suivant : 000679

A Randomized, Double-blind, Placebo-controlled Study to Assess QTc Interval Prolongation of Standard Dose Aflibercept in Cancer Patients Treated With Docetaxel

Auteurs : Pierre Maison-Blanche [France] ; Jan B. Vermorken [Belgique] ; Tuncay Goksel [Turquie] ; Jean-Pascal Machiels [Belgique] ; Sanjiv Agarwala [États-Unis] ; Sylvie Rottey [Belgique] ; Gedske Daugaard [Danemark] ; Constantin Volovat [Roumanie] ; Max Scheulen [Allemagne] ; Lisa Sengel V [Danemark] ; Dana Grecea [Roumanie] ; Alexandru Eniu [Roumanie] ; Elke J Ger [Allemagne] ; Eyal Meiri [États-Unis] ; Stefano Cascinu [Italie] ; Dirk Strumberg [Allemagne] ; Gokhan Demir [Turquie] ; Michael Clemens [Allemagne] ; Graziella Pinotti [Italie] ; Mario Nardi [Italie] ; Troy Guthrie [États-Unis] ; Emmanuelle Boelle [France] ; Emmanuelle Magherini [France]

Source :

Journal of cardiovascular pharmacology [ 0160-2446 ] ; 2013.

RBID : Pascal:13-0254044

Descripteurs français

Pascal (Inist)
- Randomisation, Etude double insu, Placebo, QT long, Aflibercept, Tumeur maligne, Homme, Malade, Docétaxel, Coeur, Toxicité, Tumeur solide, Intervalle QT, Antiangiogénique, Anticancéreux, Anti-VEGF.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aflibercept, Anti-VEGF, Antiangiogenic agent, Antineoplastic agent, Docetaxel, Double blind study, Heart, Human, Malignant tumor, Patient, Placebo, Prolonged QT interval, QT interval, Randomization, Solid tumor, Toxicity.

Affiliations:

Allemagne, Belgique, Danemark, France, Italie, Roumanie, Turquie, États-Unis
Floride, Hovedstaden, Pennsylvanie, Région de Bruxelles-Capitale, Île-de-France
Bruxelles, Copenhague, Paris

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000157
to stream PascalFrancis, to step Curation: 000B34
to stream PascalFrancis, to step Checkpoint: 000160
to stream Main, to step Merge: 000693
to stream Main, to step Curation: 000678

Le document en format XML

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<author><name sortKey="Sengel V, Lisa" sort="Sengel V, Lisa" uniqKey="Sengel V L" first="Lisa" last="Sengel V">Lisa Sengel V</name>
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<author><name sortKey="Grecea, Dana" sort="Grecea, Dana" uniqKey="Grecea D" first="Dana" last="Grecea">Dana Grecea</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Institute of Oncology "prof Dr I Chiricuta"</s1>
<s2>Cluj Napoca</s2>
<s3>ROU</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Roumanie</country>
<wicri:noRegion>Institute of Oncology "prof Dr I Chiricuta"</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eniu, Alexandru" sort="Eniu, Alexandru" uniqKey="Eniu A" first="Alexandru" last="Eniu">Alexandru Eniu</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Institute of Oncology "prof Dr I Chiricuta"</s1>
<s2>Cluj Napoca</s2>
<s3>ROU</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Roumanie</country>
<wicri:noRegion>Institute of Oncology "prof Dr I Chiricuta"</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="J Ger, Elke" sort="J Ger, Elke" uniqKey="J Ger E" first="Elke" last="J Ger">Elke J Ger</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Krankenhaus Nordwest, Medizinische Klinik II, Department of Hematology-Oncology</s1>
<s2>Frankfurt Am Main</s2>
<s3>DEU</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Frankfurt Am Main</wicri:noRegion>
<wicri:noRegion>Department of Hematology-Oncology</wicri:noRegion>
<wicri:noRegion>Frankfurt Am Main</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meiri, Eyal" sort="Meiri, Eyal" uniqKey="Meiri E" first="Eyal" last="Meiri">Eyal Meiri</name>
<affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Palm Beach Institute of Hematology and Oncology</s1>
<s2>Boynton Beach, Florida</s2>
<s3>USA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cascinu, Stefano" sort="Cascinu, Stefano" uniqKey="Cascinu S" first="Stefano" last="Cascinu">Stefano Cascinu</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Azienda Ospedaliero-Universitaria Ospedali Riuniti, Clinica di Oncologia Medica</s1>
<s2>Ancona</s2>
<s3>ITA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Ancona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Strumberg, Dirk" sort="Strumberg, Dirk" uniqKey="Strumberg D" first="Dirk" last="Strumberg">Dirk Strumberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Marienhospital Heme, Department of Hematology and Medical Oncology</s1>
<s2>Heme</s2>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Heme</wicri:noRegion>
<wicri:noRegion>Department of Hematology and Medical Oncology</wicri:noRegion>
<wicri:noRegion>Heme</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Demir, Gokhan" sort="Demir, Gokhan" uniqKey="Demir G" first="Gokhan" last="Demir">Gokhan Demir</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Istanbul Bilim Universitesi Tip Fakultesi, Department of Medical Oncology</s1>
<s2>Istanbul</s2>
<s3>TUR</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Turquie</country>
<wicri:noRegion>Istanbul</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Clemens, Michael" sort="Clemens, Michael" uniqKey="Clemens M" first="Michael" last="Clemens">Michael Clemens</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Klinikum Mutterhaus der Borromäerinnen, Klinik fur Innere Medizin I</s1>
<s2>Trier</s2>
<s3>DEU</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Trier</wicri:noRegion>
<wicri:noRegion>Klinik fur Innere Medizin I</wicri:noRegion>
<wicri:noRegion>Trier</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pinotti, Graziella" sort="Pinotti, Graziella" uniqKey="Pinotti G" first="Graziella" last="Pinotti">Graziella Pinotti</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Ospedale Di Circolo E Fondazione Macchi</s1>
<s2>Varese</s2>
<s3>ITA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Ospedale Di Circolo E Fondazione Macchi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nardi, Mario" sort="Nardi, Mario" uniqKey="Nardi M" first="Mario" last="Nardi">Mario Nardi</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Azienda Ospedaliera Bianchi Melacrino Morelli, Divisione di Oncologia</s1>
<s2>Reggio di Calabria</s2>
<s3>ITA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Reggio di Calabria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guthrie, Troy" sort="Guthrie, Troy" uniqKey="Guthrie T" first="Troy" last="Guthrie">Troy Guthrie</name>
<affiliation wicri:level="2"><inist:fA14 i1="20"><s1>Baptist Regional Cancer Institute</s1>
<s2>Jacksonville, FL</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Floride</region>
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</affiliation>
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<author><name sortKey="Boelle, Emmanuelle" sort="Boelle, Emmanuelle" uniqKey="Boelle E" first="Emmanuelle" last="Boelle">Emmanuelle Boelle</name>
<affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Sanofi R&D, R&D Oncology Division</s1>
<s2>Vitry-sur-Seine</s2>
<s3>FRA</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Vitry-sur-Seine</wicri:noRegion>
<wicri:noRegion>R&D Oncology Division</wicri:noRegion>
<wicri:noRegion>Vitry-sur-Seine</wicri:noRegion>
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</author>
<author><name sortKey="Magherini, Emmanuelle" sort="Magherini, Emmanuelle" uniqKey="Magherini E" first="Emmanuelle" last="Magherini">Emmanuelle Magherini</name>
<affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Sanofi R&D, R&D Oncology Division</s1>
<s2>Vitry-sur-Seine</s2>
<s3>FRA</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Vitry-sur-Seine</wicri:noRegion>
<wicri:noRegion>R&D Oncology Division</wicri:noRegion>
<wicri:noRegion>Vitry-sur-Seine</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of cardiovascular pharmacology</title>
<title level="j" type="abbreviated">J. cardiovasc. pharmacol.</title>
<idno type="ISSN">0160-2446</idno>
<imprint><date when="2013">2013</date>
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</series>
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<seriesStmt><title level="j" type="main">Journal of cardiovascular pharmacology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aflibercept</term>
<term>Anti-VEGF</term>
<term>Antiangiogenic agent</term>
<term>Antineoplastic agent</term>
<term>Docetaxel</term>
<term>Double blind study</term>
<term>Heart</term>
<term>Human</term>
<term>Malignant tumor</term>
<term>Patient</term>
<term>Placebo</term>
<term>Prolonged QT interval</term>
<term>QT interval</term>
<term>Randomization</term>
<term>Solid tumor</term>
<term>Toxicity</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Randomisation</term>
<term>Etude double insu</term>
<term>Placebo</term>
<term>QT long</term>
<term>Aflibercept</term>
<term>Tumeur maligne</term>
<term>Homme</term>
<term>Malade</term>
<term>Docétaxel</term>
<term>Coeur</term>
<term>Toxicité</term>
<term>Tumeur solide</term>
<term>Intervalle QT</term>
<term>Antiangiogénique</term>
<term>Anticancéreux</term>
<term>Anti-VEGF</term>
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<li>Belgique</li>
<li>Danemark</li>
<li>France</li>
<li>Italie</li>
<li>Roumanie</li>
<li>Turquie</li>
<li>États-Unis</li>
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<region><li>Floride</li>
<li>Hovedstaden</li>
<li>Pennsylvanie</li>
<li>Région de Bruxelles-Capitale</li>
<li>Île-de-France</li>
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<settlement><li>Bruxelles</li>
<li>Copenhague</li>
<li>Paris</li>
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<tree><country name="France"><region name="Île-de-France"><name sortKey="Maison Blanche, Pierre" sort="Maison Blanche, Pierre" uniqKey="Maison Blanche P" first="Pierre" last="Maison-Blanche">Pierre Maison-Blanche</name>
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<name sortKey="Boelle, Emmanuelle" sort="Boelle, Emmanuelle" uniqKey="Boelle E" first="Emmanuelle" last="Boelle">Emmanuelle Boelle</name>
<name sortKey="Magherini, Emmanuelle" sort="Magherini, Emmanuelle" uniqKey="Magherini E" first="Emmanuelle" last="Magherini">Emmanuelle Magherini</name>
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<country name="Belgique"><noRegion><name sortKey="Vermorken, Jan B" sort="Vermorken, Jan B" uniqKey="Vermorken J" first="Jan B." last="Vermorken">Jan B. Vermorken</name>
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<name sortKey="Machiels, Jean Pascal" sort="Machiels, Jean Pascal" uniqKey="Machiels J" first="Jean-Pascal" last="Machiels">Jean-Pascal Machiels</name>
<name sortKey="Rottey, Sylvie" sort="Rottey, Sylvie" uniqKey="Rottey S" first="Sylvie" last="Rottey">Sylvie Rottey</name>
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<country name="Turquie"><noRegion><name sortKey="Goksel, Tuncay" sort="Goksel, Tuncay" uniqKey="Goksel T" first="Tuncay" last="Goksel">Tuncay Goksel</name>
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<name sortKey="Demir, Gokhan" sort="Demir, Gokhan" uniqKey="Demir G" first="Gokhan" last="Demir">Gokhan Demir</name>
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<country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Agarwala, Sanjiv" sort="Agarwala, Sanjiv" uniqKey="Agarwala S" first="Sanjiv" last="Agarwala">Sanjiv Agarwala</name>
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<name sortKey="Guthrie, Troy" sort="Guthrie, Troy" uniqKey="Guthrie T" first="Troy" last="Guthrie">Troy Guthrie</name>
<name sortKey="Meiri, Eyal" sort="Meiri, Eyal" uniqKey="Meiri E" first="Eyal" last="Meiri">Eyal Meiri</name>
</country>
<country name="Danemark"><region name="Hovedstaden"><name sortKey="Daugaard, Gedske" sort="Daugaard, Gedske" uniqKey="Daugaard G" first="Gedske" last="Daugaard">Gedske Daugaard</name>
</region>
<name sortKey="Sengel V, Lisa" sort="Sengel V, Lisa" uniqKey="Sengel V L" first="Lisa" last="Sengel V">Lisa Sengel V</name>
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<country name="Roumanie"><noRegion><name sortKey="Volovat, Constantin" sort="Volovat, Constantin" uniqKey="Volovat C" first="Constantin" last="Volovat">Constantin Volovat</name>
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<name sortKey="Eniu, Alexandru" sort="Eniu, Alexandru" uniqKey="Eniu A" first="Alexandru" last="Eniu">Alexandru Eniu</name>
<name sortKey="Grecea, Dana" sort="Grecea, Dana" uniqKey="Grecea D" first="Dana" last="Grecea">Dana Grecea</name>
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<country name="Allemagne"><noRegion><name sortKey="Scheulen, Max" sort="Scheulen, Max" uniqKey="Scheulen M" first="Max" last="Scheulen">Max Scheulen</name>
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<name sortKey="Clemens, Michael" sort="Clemens, Michael" uniqKey="Clemens M" first="Michael" last="Clemens">Michael Clemens</name>
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<name sortKey="Strumberg, Dirk" sort="Strumberg, Dirk" uniqKey="Strumberg D" first="Dirk" last="Strumberg">Dirk Strumberg</name>
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<country name="Italie"><noRegion><name sortKey="Cascinu, Stefano" sort="Cascinu, Stefano" uniqKey="Cascinu S" first="Stefano" last="Cascinu">Stefano Cascinu</name>
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<name sortKey="Pinotti, Graziella" sort="Pinotti, Graziella" uniqKey="Pinotti G" first="Graziella" last="Pinotti">Graziella Pinotti</name>
</country>
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A Randomized, Double-blind, Placebo-controlled Study to Assess QTc Interval Prolongation of Standard Dose Aflibercept in Cancer Patients Treated With Docetaxel

A Randomized, Double-blind, Placebo-controlled Study to Assess QTc Interval Prolongation of Standard Dose Aflibercept in Cancer Patients Treated With Docetaxel

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